Figure 2
Viral genome content of control and FX-binding ablated Ad vectors at high dose at an early time point. Viral genome content of liver, spleen, heart, lung, kidney, intestines and pancreas tissue 1 hour after the administration of 1 × 1011 vp of Ad5 and Ad5-HVR5*7*E451Q in control (CL−) or macrophage-depleted mice (CL+). DNA was extracted from all tissues and viral genomes quantified using quantitative PCR. (*P < .05 vs Ad5, n = 5).
