Quinine-dependent mAb 314.1 promotes platelet destruction in NOD/scid mice given quinine. Human platelets were infused into NOD/scid mice followed by intraperitoneal injection of 50 μg of mAb 314.1 or control monoclonal. One hour later (time 0) and at 5 hours, buffer or quinine (74 μg), was injected intraperitoneally Platelet survival was markedly shortened in mice given mAb 314.1 and quinine (triangles) but not in mice given the mAb alone (squares) or quinine plus an irrelevant mAb (circles). Values shown are the average ± 1 SEM of triplicate experiments. ***P < .001 relative to controls.