Figure 7
Figure 7. 9p24.1 amplification targets, consequences, and associated treatment options. 9p24.1 amplification increases PD-1 ligand (PD-L1 and PD-L2) and JAK2 copy numbers, augments JAK2/STAT1 activity, induces PD-1 ligand expression, and stimulates HL proliferation.

9p24.1 amplification targets, consequences, and associated treatment options. 9p24.1 amplification increases PD-1 ligand (PD-L1 and PD-L2) and JAK2 copy numbers, augments JAK2/STAT1 activity, induces PD-1 ligand expression, and stimulates HL proliferation.

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