Figure 4
Figure 4. Activation and proliferation of memory T cells after treatment with IL-15 occurs in multiple tissues. Frequency of TCM (CCR7+CD95+) and TEM (CCR7−CD95+) T cells expressing Ki-67 and CD25 (CD4+) or Ki-67 and CD38 (CD8+) in different tissues of the body at day 13 after IL-15 treatment initiation. Expression of CD122 (MFI) was also shown in the same cell subsets. Data were expressed as in Figure 3B. MLN, mesenteric lymph node; ALN, axillary lymph node; ILN, inguinal lymph node; Spl, spleen; BM, bone marrow; Jej, jejunum. *P < .05 after Wilcoxon rank test versus sham.

Activation and proliferation of memory T cells after treatment with IL-15 occurs in multiple tissues. Frequency of TCM (CCR7+CD95+) and TEM (CCR7−CD95+) T cells expressing Ki-67 and CD25 (CD4+) or Ki-67 and CD38 (CD8+) in different tissues of the body at day 13 after IL-15 treatment initiation. Expression of CD122 (MFI) was also shown in the same cell subsets. Data were expressed as in Figure 3B. MLN, mesenteric lymph node; ALN, axillary lymph node; ILN, inguinal lymph node; Spl, spleen; BM, bone marrow; Jej, jejunum. *P < .05 after Wilcoxon rank test versus sham.

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