Microarray analysis. In this supervised principal component analysis (PCA) each patient is represented by a colored sphere. Ellipsoids are drawn with 2-fold standard deviations. (A) The gene expression signature is given for the top 500 probe sets differentially detected between 24 cases with AML-MLD-sole and 56 cases displaying AML-NOS. (B) The gene expression signature is given for the top 500 probe sets differentially expressed between 80 cases AML-NOS plus AML-MLD-sole and 16 AML-MRC cases on the basis of cytogenetics or a MDS history. Detailed information on the significantly differentially expressed probe sets and their functional annotation is available in supplemental data.