Figure 2
Molecular model of ADAMTS13 MP-Dis based on the crystal structures of ADAMTS1, -4, and -5. The active site containing a Zn2+ ion is circled in white and labeled. R349 and L350 in the Dis domain known to be important for VWF proteolysis are labeled. VR1, -2, and -3 (shown in dark gray) flank the active site cleft. The region circled in black is enlarged and shown in cartoon below to better depict the position of VR1, -2, and -3. Amino acids at the start and end of each VR region are identified.
