The key proteins regulating the fate of newly synthesized BCR-ABL oncoprotein. In this model, Bag1 and Hsc70 compete for binding to immature BCR-ABL. Bag1 binding will traffic the BCR-ABL for degradation in the proteasome using the CHIP ubiquitin ligase. Conversely, Hsc70 binding will protect BCR-ABL and allow it to fully mature, when it is then bound/protected by Hsp90. Alternatively, any unbound mature BCR-ABL is ubiquitinated by Cbl and degraded in the lysosome (adapted from Figure 7 of the Tsukahara and Maru article).