Antagonizing effect of FTY720 and FTY720-P on leukemogenesis. Schematic representation on the effect of PP2A-activating drugs (PADs, eg, FTY720) and sphingosine-1-phosphate-receptor-1 agonists (eg, FTY720-P) on leukemogenesis through the opposite effect on the interplay between oncogenic kinase (eg, Jak2^V617F and BCR-ABL1) signaling and tumor suppressor (ie, PP2A) activity.