American Society of Hematology

Figure 6

$Figure 6. 34-1-2s causes significant lung damage in SCID mice. BALB/c mice (●, N = 5) or SCID mice (○, N = 5) were injected with 2.3 mg/kg 34-1-2s mAb and (A) SO2 levels, and (B) Cst were determined at the indicated time points. Histologic micrographs (C; original magnification ×40, see “Lung histology”) reveal moderate leukocyte infiltration in BALB/c mice but marked cellular infiltration and septal thickening in SCID mice 2 hours after infusion of 34-1-2s mAb (500 μg). Interstitial space fraction (D) as a quantitative measure of septal thickening was determined intravital microscopic recordings in BALB/C and SCID mice at baseline and 30 minutes after infusion of 34-1-2s mAb (50 μg). Representative dark-field images are given in supplemental Figure 2.$

34-1-2s causes significant lung damage in SCID mice. BALB/c mice (●, N = 5) or SCID mice (○, N = 5) were injected with 2.3 mg/kg 34-1-2s mAb and (A) SO₂ levels, and (B) C_st were determined at the indicated time points. Histologic micrographs (C; original magnification ×40, see “Lung histology”) reveal moderate leukocyte infiltration in BALB/c mice but marked cellular infiltration and septal thickening in SCID mice 2 hours after infusion of 34-1-2s mAb (500 μg). Interstitial space fraction (D) as a quantitative measure of septal thickening was determined intravital microscopic recordings in BALB/C and SCID mice at baseline and 30 minutes after infusion of 34-1-2s mAb (50 μg). Representative dark-field images are given in supplemental Figure 2.

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