VEGF and FGF increase the frequency of excess centrosomes in endothelial cells independent of proliferative changes. (A) Percentage of HUVECs with more than 2 centrosomes in indicated conditions (low VEGF/low FGF, n = 1594; high VEGF, n = 1717; high FGF, n = 1563; high VEGF/high FGF, n = 866). **P < .001 vs low VEGF/low FGF. ***P < .0001 vs low VEGF/low FGF. (B) HUVEC growth curves in low and high VEGF, expressed as fold increase in cell number relative to t = 0. Solid line indicates low VEGF conditions; and dashed line, high VEGF conditions. All experiments were performed at least 3 times.