Model for VEGF regulation of endothelial centrosome duplication. A schematic of proposed signaling to regulate centrosome duplication in endothelial cells. In this model, VEGF promotes MEK/ERK and AKT signaling, leading to increased levels of cyclin E. Cyclin E binds Cdk2 to activate cyclin E/Cdk2 activity and promotes centrosome duplication, perhaps via phosphorylation of NPM. Elevated VEGF levels lead to abnormally high Cdk2/cyclin E activity and centrosome overduplication.