Anti-cytokine autoantibodies in patients with thymic neoplasia. Shown are results from 30 healthy volunteers (HVs), 12 patients with thymic neoplasia without opportunistic infection (Thym/OI−), and 5 patients thymic neoplasia with opportunistic infection (Thym/OI+). Each symbol represents a sample from one patient. The antibody titers in LU for (A) anti–IFN-γ, (B) anti–IFN-α, (C) anti–IFN-ω, (D) anti–IFN-λ, (E) anti–IFN-β, and (F) anti–IFN-ε, (G) anti–IL-12p40 (H) anti–IL-12p35, (I) anti–IL-17, (J) anti-BAFF, (K) anti–IL-1α, and (L) anti–TNF-α antibody titers are plotted on the y-axis using a log₁₀ scale. The geometric mean antibody titer for each group is shown by the short line. The dashed and solid lines represent the cutoff levels for determining seropositivity and are derived from the mean + 3 SDs and mean + 5 SDs of the antibody titer of the 30 controls, respectively. P values for the different groups were calculated using the Mann-Whitney U test.