The c.-1522_-1510del13 VWF promoter mutation. (A) VWF sequence showing the location of the 13-bp deletion within the promoter of the VWF gene, 48 bp upstream of the transcription start site. The 2 Ets binding sites are indicated. (B) Schematic representation of the VWF promoter fragment including 1248 bp of 5′ flanking sequence, exon 1 and intron 1 (total length 2722 bp). The CAAT and TATA box locations relative to the mutation site are shown.