CD4 T cells specific for endogenous antigens can drive immune reconstitution disease. (A) M avium–infected and –uninfected male or female TCRα^−/− mice received Marilyn (antimale TCR Tg) CD4 T cells (2 × 10⁶) isolated from female donor mice. (B) Survival of mice in shown in panel A. (C) IFNγ and (D) total nitrate were measured in the serum of mice shown in panel A on day 3 after transfer. All data are representative of at least 2 independent experiments.