Treatment of spontaneous TCL1 leukemias with R788. (A) 8 Eμ-TCL1 transgenic mice that had developed spontaneous leukemia were treated for 42 days with R788. Shown are the percentage and absolute number of malignant CD5⁺/B220⁺ cells before, during and after therapy. (B) Flow cytometric analysis of peripheral blood samples from mouse TCL1-121 collected before (day 0), during (days 16 and 42), and after therapy (days 66, 80, 94, and 150).