Dose dependence of ATL146e to reduce lung injury and inflammation in NY1DD mice. NY1DD mice (N = 4) were treated for 3 days with a constant infusion of vehicle or ATL146e (1 ng/kg/minute, 10 ng/kg/minute, and 30 ng/kg/minute, osmotic pump). All parameters were found to be maximally improved by 10 ng/kg/minute. The solid and dashed lines represent the mean ± SEM of parameters from congenic C57BL/6 mice. Data were analyzed by 1-way ANOVA with Neuman-Keuls posttesting. *P < .05 vs day 0.