Prognostic value of Ang2 in combination with VEGF. (A) Patients are stratified in high and low VEGF subsets based on VEGF plasma levels (cutoff = 148 pg/mL). High VEGF CLLs have significantly shorter TTFT compared with low VEGF CLLs (P = .028, log-rank test). (B) Ang2 plasmatic level adds prognostic power in defining TTFT inside CLL subsets with high and low VEGF plasma level (P < .001). The cutoff level for Ang2 is 2459 pg/mL and for VEGF is the 75th percentile (148 pg/mL).