RFS in gene expression cluster groups. RFS is shown for each of the high CV clusters (A), COPA clusters (B), and ROSE clusters (C). Only the H6, C6, and R6 clusters (curves shown in blue) have a significantly better outcome compared with the entire cohort (dense line), whereas the H8, C8, and R8 clusters (curves shown in red) have a significantly poorer RFS. Hazard ratios and P values are shown in the bottom left of each panel.