SNP rs6457327 predicts time to and risk of transformation of FL. (A) Kaplan-Meier plots of the percentage of FL cases with transformation against time from diagnosis for rs6457327 genotypes. Genotype groups with respective number of cases and the log-rank test statistic P value are indicated on the right. (B) Number of cases that transformed for each rs6457327 genotype group. The χ2P value is indicated. (C) Final adjusted models for risk of transformation and time to transformation. These were generated following multivariate analysis incorporating potential confounders using logistic regression for risk of transformation and Cox regression for time to transformation. No cases with stable disease as response to first treatment transformed, so no data are available. CI indicates confidence interval; HR, hazard ratio; Int, intermediate; PR, partial response; CR(u), complete response unconfirmed; CR, complete response; and NA, not applicable.
