Immunohistochemical analysis on tissue microarrays. Cases were considered as positive when > 30% cells were stained (Olympus BX41 microscope equipped with an Olympus UPlanFI × 40/075 or 20/050 numerical aperture objectives and Olympus CAMEDIA C-7070 camera; Olympus Italia Srl; magnification ×400; colors balanced after acquisition with Adobe Photoshop). BLs mainly consisted of neoplastic elements with typical morphology in the majority of cases (GIEMSA; GM). SPARC and CYR61 stainings are shown in BL and reactive lymph nodes (LNs). In both instances, nonneoplastic B cells were mostly negative, with scattered CYR61 positivities in GC and mantle (M) zones.