Risk-adapted therapy in primary myelofibrosis. DIPSS-plus indicates Dynamic International Prognostic Scoring System (DIPSS)-plus prognostic model for primary myelofibrosis⁴⁰ ; Int, intermediate; yrs, years; CIC, conventional-intensity conditioning; RIC, reduced-intensity conditioning; allo-SCT, allogeneic stem cell transplantation. *Conventional drug therapy includes erythropoiesis-stimulating agents, androgens, danazol, corticosteroids, thalidomide, lenalidomide, hydroxyurea, and cladribine. Please see text about which agent is used when.