Figure 6
![Figure 6. Pak1 and RAC1 inhibition phenocopy the effects of HDACIs on pMLC levels. (A) Western blot performed on Meg-01 cells treated for 24 hours with 10μM of the PAK1 inhibitor WR PAK18 showing an increase in pMLC levels. (B) Western blot performed on Meg-01 cells transduced with a constitutively activate (CA Rac1) or dominant-negative (DN Rac1) Rac1, showing a decrease and increase, respectively, in pMLC levels compared with empty vector (murine stem cell virus [MSCV]) alone.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/117/13/10.1182_blood-2010-11-318055/4/zh89991168620006.jpeg?Expires=1735834802&Signature=kqqPMRNIL9xKsWFOQAy012eNO2pjTmC0Mp4HF8SkRmT08XayNDYkj9QvhMUP6SK6~Zd5flfpTzJF909S5TcGawbyDFt6g9lSpqi3iK6WzUIN0mL6enHY~Mp~X8IWmSb9lRWVGjUzF9QjpseSocHl48THsARHM3Mb6hg58KGcmF6TTFLDnqV-c9PykJ7s3ARgHUXN34UmOxug-I7f9octTVy5unnlb2snJ3iRMBFlk7sZoyt0roHLnDUYa9YccivhMeMiV0tqskz5niutnwgCOicpzzbnuI7~bQC98NAARtSzogzslZ5sl4EZoUgl7aWlVlkJWZe4Tz478Xa6G3K9Tw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Pak1 and RAC1 inhibition phenocopy the effects of HDACIs on pMLC levels. (A) Western blot performed on Meg-01 cells treated for 24 hours with 10μM of the PAK1 inhibitor WR PAK18 showing an increase in pMLC levels. (B) Western blot performed on Meg-01 cells transduced with a constitutively activate (CA Rac1) or dominant-negative (DN Rac1) Rac1, showing a decrease and increase, respectively, in pMLC levels compared with empty vector (murine stem cell virus [MSCV]) alone.
