Figure 5
Figure 5. NOTCHIC expression can maintain Tet-o-MYC/MIT-NOTCHIC T-ALL tumors. (A) Schematic for generation of Tet-o-MYC/MIT-NOTCHIC tumors. (B) Diagram of retroviral constructs. (C) Death curves for mice reconstituted with Tet-o-MYC bone marrow infected with MIT-NOTCHIC (left panel) and MIT-GFP (right panel). (D) Spleens from nonregressing Tet-o-MYC/MIT-NOTCHIC. (E) FACS analysis using α-CD4-PE and α-CD8-PerCP-Cy5.5 antibodies on single-cell suspensions from spleens of moribund nonregressing Tet-o-MYC/MIT-NOTCHIC treated with Dox for the indicated times.

NOTCHIC expression can maintain Tet-o-MYC/MIT-NOTCHIC T-ALL tumors. (A) Schematic for generation of Tet-o-MYC/MIT-NOTCHIC tumors. (B) Diagram of retroviral constructs. (C) Death curves for mice reconstituted with Tet-o-MYC bone marrow infected with MIT-NOTCHIC (left panel) and MIT-GFP (right panel). (D) Spleens from nonregressing Tet-o-MYC/MIT-NOTCHIC. (E) FACS analysis using α-CD4-PE and α-CD8-PerCP-Cy5.5 antibodies on single-cell suspensions from spleens of moribund nonregressing Tet-o-MYC/MIT-NOTCHIC treated with Dox for the indicated times.

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