Exhausted lymphopoiesis in HIV-elite controller progressors. (A) Absolute counts of CD34⁺ CD45^low Lin⁻ cells and frequency of lymphoid (CD45RA⁺ CD10⁺ CD117⁻ CD38⁺) HPCs in HIV-elite controller nonprogressors (Cnp; CD4⁺ T-cell count > 500 cells/μL; n = 12) and progressors (Cp; CD4⁺ T-cell count < 350 cells/μL; n = 10). For comparison, counts in middle-aged (M; n = 27) and elderly (O; n = 26) adults are also shown. (B) Numbers of white (CFU-GM and CFU-GEMM) progenitor CFUs generated from CD34⁺-sorted cells of HIV-elite controller nonprogressors or progressors, and (C) absolute naive CD4⁺ or CD8⁺ T-, B-, and NK-cell counts in HIV-elite controller or comparative donor groups. Bars indicate the median. The Kruskal-Wallis test was used for group comparison. *P < .05, **P < .01, and ***P < .001.