Figure 6
Figure 6. A schematic representation of the role of ubiquitylation and SUMOylation in Tax and NEMO trafficking and activation of NF-κB. (A) K-63 ubiquitylated Tax targets Tax and NEMO to the centrosome. (B) Tax ubiquitylation targets Tax and NEMO to Ubc9/SUMO enriched nuclear bodies. (C) Tax and NEMO SUMOylation. (D) Bidirectional trafficking of Tax between nuclear bodies and the centrosome. (E) Tax shuttles among nuclear bodies. (F) Tax SUMOylation targets NEMO to the centrosome. (G) Recruitment of the catalytic IKK subunits to the centrosome. (H) Formation of the IKK complex. (I) Tax-free active IKK is liberated into the cytosol. (Alphabets do not necessarily indicate a chronological sequence of events.)

A schematic representation of the role of ubiquitylation and SUMOylation in Tax and NEMO trafficking and activation of NF-κB. (A) K-63 ubiquitylated Tax targets Tax and NEMO to the centrosome. (B) Tax ubiquitylation targets Tax and NEMO to Ubc9/SUMO enriched nuclear bodies. (C) Tax and NEMO SUMOylation. (D) Bidirectional trafficking of Tax between nuclear bodies and the centrosome. (E) Tax shuttles among nuclear bodies. (F) Tax SUMOylation targets NEMO to the centrosome. (G) Recruitment of the catalytic IKK subunits to the centrosome. (H) Formation of the IKK complex. (I) Tax-free active IKK is liberated into the cytosol. (Alphabets do not necessarily indicate a chronological sequence of events.)

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