Plasma coagulation parameters from mice administered a lethal dose of LPS. WT mice and PC^−/−PC(tg4)/TF^−/−hTF(tg) mice were administered 10 μg LPS/g body weight. (A). Blood was collected at t = 0 and t = 12 hours in citrate and platelet counts determined. Plasma was then obtained for determinations of the (B) aPTT, (C) PT after addition of thromboplastin, (D) clottable Fg levels, (E) TAT levels, and (F) D-dimer levels. Black bars, resting WT mice; white bars, resting PC^−/−PC(tg4)/TF^−/−hTF(tg) mice; gray bars, WT mice at 12 hours post-LPS; vertical striped bars, PC(tg4)/TF^−/−hTF(tg) mice at 12 hours post-LPS. *n = 8-10, P < .05.