The inflammatory response of mice to a lethal dose of LPS. Plasma was obtained from WT mice and mice at 12 hours post-LPS (10 μg LPS/g body weight). The levels of (A) PC, (B) MIP-2, and (C) IL-6 were determined by ELISA. Black bars, resting WT mice; white bars, resting PC^−/−PC(tg4)/TF^−/−hTF(tg) mice; gray bars, WT mice at 12 hours post-LPS; vertical striped bars, PC(tg4)/TF^−/−hTF(tg) mice at 12 hours post-LPS. *n = 6-8, P < .05.