Schematic representation of the pleiotropic effects of Activin A on immune cells. At the bottom of the figure (in the box) the data on macrophage polarization reported by Sierra-Filardi et al are summarized.1 LC indicates Langerhans cells; iDC, immature dendritic cells; mDC, mature dendritic cells; MC, mast cells; +, stimulation; −, inhibition; and =, no effect. Professional illustration by Debra Dartez.