Large B-cell lymphomas with a phenotype of terminal B-cell differentiation. This group of tumors is characterized by a down-regulation of the mature B-cell differentiation program and expression of plasma cell markers. Most of these tumors appear in immunocompromised patients. The tumor cells are often infected by EBV, human herpesvirus 8 (HHV8), or both. ALK⁺ large B-cell lymphoma (LBCL) occurs in immunocompetent patients and is not virally transformed. LyG indicates lymphomatoid granulomatosis; DLBCL, diffuse large B-cell lymphoma; PBL, plasmablastic lymphoma; PEL, primary effusion lymphoma; LBCL-MCD, large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease.