Expression analysis of oncomir-1/miR-17-92 and its paralogs miR-106a-363 and miR-106b-25. (A) Hierarchical clustering of the miRNA expression frequencies. The flags (red indicates oncomir-1/miR-17-92; blue, miR-106a-363; and black, miR-106b-25) show where each miRNA is induced. The results suggest sequential expression of the 3 clusters in consecutive developmental stages. (B) The architecture of the paralogs. Similarly colored miRNAs within each cluster have identical seed sequences. (C) The summed counts for each seed family are shown (inset is a rescaling of the last 3 seed families), suggesting biphasic expression of the seed families.