Immunohistochemical features and EBER in situ hybridization of AR-EBVLPD. (A-F) Poly-N with prominent HRS-like cells. (A) Reduced expression of CD20. (B) The HRS-like cells are CD30+. There is nuclear expression of PAX5 (C), Oct.2 (D), and BOB1 (E). (F) Occasional cells are positive for CD15. (G) Reactive follicular hyperplasia. Germinal center shows intense EBER positivity. (H) Reactive paracortical hyperplasia. There is paracortical/interfollicular distribution of EBER+ cells. (I) EBVMCU. Note superficial distribution of EBER+ cells. (J) Poly-N. High concentration of EBER+ cells. (K) Poly-E. Arterial wall infiltrated by EBER+ B cells. Original magnifications, ×20 (I); ×40 (G-H); ×100 (J-K); ×400 (A-E); and ×600 (F).