Shear-induced activation in the presence of CD62P-blocking antibody and soluble platelet agonist inhibition. (A) Platelet CD62P expression, (B) PM-Agg formation, and (C) monocyte CD11b expression. Flow cytometry was performed in 3 healthy donors under control conditions, after shear stress with and without CD62P blocking antibody or soluble platelet agonist inhibition. Solid bars and error bars represent mean ±SD. P < .05 for 1-way analysis of variance and *P < .05 for difference compared with shear group by post hoc Tukey test.