ENCODE data display beginning from the top row down of ChIP-seq signals in K562 cells on occupancy of GATA-1, GATA-2, BRG1, Ini1, RNA polymerase 2, and histones H3K4Me1 and H3K4Me3. Also shown is genomic footprinting, RNA transcript^22,23  both also in K562 cells and ESFERR regulatory potential,²⁴  among different species. The vertical red lines represent the site of the 3-bp deletion polymorphism (chromosome 6: 135 460 326-135 460 328), which is in complete LD with rs9399137. The green lines represent the site of rs9399137 (chromosome 6: 135 460 711), the SNP that was found in multiple GWASs to have the most significant P value in HbF association. These ENCODE data were generated by the ENCODE consortium and are available on the Genome Browser at UCSC.²¹  The GATA-1, GATA-2, BRG1, Ini1, and RNA Polymerase II ChIP-Seq data were generated by the laboratories of M. Snyder, M. Gerstein, and S. Weissman at Yale; P.J. Farnham at the University of California-Davis; and K. Struhl at Harvard. The H3K4Me1 and H3K4Me3 data were generated by the Bernstein Laboratory at the Broad Institute. The Digital Genomic Footprinting data were generated by the University of Washington ENCODE group. The GIS RNA-seq data were generated by the Genome Institute of Singapore.