American Society of Hematology

Figure 3

$Figure 3. The KIR2DL1+ NK cell compartment is influenced by the allelic state of KIR2DL2/3. (A) The frequency of NK cells expressing KIR2DL1 and KIR2DL2/3 is shown for donors with group B haplotypes (A/B and B/B) who were divided into 3 groups according to the allelic state of the KIR2DL2/3 gene. Data are represented as box plots: that represent the median and 25/75 percentiles, whiskers the lowest and largest non-outlier data points (at most 1.5 times the box width). Statistical significance was determined by ANOVA at ***P < .001. (B-C) Frequency of NK cells expressing KIR2DL1 (B) or KIR2DL2/3 (C) in a CD107 mobilization assay against K562 target cells. Samples from donors without (n = 14) and with (n = 11) KIR2DL2 genes are presented in scatter plots with each dot representing 1 sample. Results are expressed as fraction of all CD56+ NK cells. Statistical significance was calculated by 2-tailed t test as **P < .01.$

The KIR2DL1⁺ NK cell compartment is influenced by the allelic state of KIR2DL2/3. (A) The frequency of NK cells expressing KIR2DL1 and KIR2DL2/3 is shown for donors with group B haplotypes (A/B and B/B) who were divided into 3 groups according to the allelic state of the KIR2DL2/3 gene. Data are represented as box plots: that represent the median and 25/75 percentiles, whiskers the lowest and largest non-outlier data points (at most 1.5 times the box width). Statistical significance was determined by ANOVA at ***P < .001. (B-C) Frequency of NK cells expressing KIR2DL1 (B) or KIR2DL2/3 (C) in a CD107 mobilization assay against K562 target cells. Samples from donors without (n = 14) and with (n = 11) KIR2DL2 genes are presented in scatter plots with each dot representing 1 sample. Results are expressed as fraction of all CD56⁺ NK cells. Statistical significance was calculated by 2-tailed t test as **P < .01.

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