Elevated fibrinogen shortens the time to vessel occlusion after FeCl₃ injury. Wild-type C57Bl/6 mice were infused with HBS or fibrinogen (plasminogen-, fibronectin-, and VWF-depleted or plasminogen-, fibronectin-, VWF-, and factor XIII-depleted) to 170% of normal. Thrombosis was induced by FeCl₃ application to the carotid artery (A) or saphenous vein (B), and the TTO was determined by flow probe or Doppler, respectively. In vessels that did not occlude, the TTO was recorded as 45 minutes. Each point represents a separate mouse. Lines indicate median values.