Decrease in the number of NK cells, MDCs, and PDCs and the detection of EBER1 and type I IFN in the plasma of infected NOG-hCD34 mice. (A-C) Human MNC numbers in spleen. The cell numbers of CD4⁺ T-cell subset (whole, CD4⁺CD45⁺; naive, CD4⁺CD45RA⁺CD45⁺; memory, CD4⁺CD45RO⁺CD45⁺; Treg, CD4⁺FOXP3⁺CD45⁺; A), NK cell (CD56⁺CD3⁻CD45⁺; B), and DC subset (MDC, Lineage⁻[CD3⁻CD14⁻CD19⁻CD56^–CD303⁻]HLA-DR^highCD11c^highCD45⁺; PDC, CD303⁺CD45⁺; C) in spleen of mock-infected mice (n = 6) and EBV-infected mice (n = 6) are shown. Asterisks represent statistic significance (P < .05 by Welch t test) versus the value obtained from the mock-infected mice. (D) Quantification of IFN-β in plasma. The concentration of IFN-β in the plasma of mock-infected mice (n = 5) and EBV-infected mice (n = 14) was quantified by ELISA. n.s. indicates no statistical significance. (E) Quantification of EBER1 in plasma. The concentration of EBER1 in plasma of 8 EBV-infected mice and a mock-infected mouse was quantified as previously described.³¹  The mouse numbers correspond with those in Tables 1 and 2.