American Society of Hematology

Figure 1

$Figure 1. Overall view of the protocol. The conditioning regimen included total body irradiation (TBI) of 8 Gy in a single fraction at 16 cGy/m, thiotepa (TT) at 4 mg/kg/d, cyclophosphamide (CTX) at 35 mg/kg/d, and fludarabine at 40 mg/sqm/d. On day −4, the patient received freshly isolated donor Tregs, followed by a megadose of CD34+ cells and Tcons (day 0). No posttransplantation immunosuppression was given.$

Overall view of the protocol. The conditioning regimen included total body irradiation (TBI) of 8 Gy in a single fraction at 16 cGy/m, thiotepa (TT) at 4 mg/kg/d, cyclophosphamide (CTX) at 35 mg/kg/d, and fludarabine at 40 mg/sqm/d. On day −4, the patient received freshly isolated donor Tregs, followed by a megadose of CD34⁺ cells and Tcons (day 0). No posttransplantation immunosuppression was given.

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