Differential regulation of BLIMP1α target genes by LMP-1 in GC B cells. Quantitative RT-PCR was used to measure the relative quantity of BCL6, PAX5, IRF4, and MYC mRNA in LMP-1-expressing GC B cells or BLIMP1α-expressing GC B cells presented as 2^{−ΔΔ CT} values compared with vector only-transfected GC B cells. The expression of BCL6 and PAX5 was down-regulated, and that of IRF4 up-regulated by both LMP-1 and BLIMP1α. In contrast, whereas MYC was down-regulated by BLIMP1α, it was up-regulated by LMP-1.