Schematic illustration of the potential regulation by LMP-1 of a reciprocal regulatory loop involving BLIMP1α and MYC. LMP-1 might act initially to down-regulate BLIMP1α, which would release the BLIMP1α-mediated suppression of MYC. The up-regulation of MYC would lead to further suppression of BLIMP1α. Alternatively, LMP-1 might initially activate MYC expression.