Figure 1
Figure 1. Transgenic mice express functional IL-22R1 on lymphocytes. (A) A schematic diagram of the IL-22R1 transgene driven by a mouse CD2 promoter. (B) Southern blot analysis of IL-22R1 transgene in founders on a C57BL/6 background. (C) Zebra plots of flow cytometric analysis for IL-22R1 expression on myeloid (CD11b+), T (CD3+), and B (CD19+) cells in peripheral blood leukocytes. (D) Western blot analysis of STAT3 phosphorylation (Tyr705) in the thymus, lymph nodes, and spleen from tg founders and nontransgenic littermates.

Transgenic mice express functional IL-22R1 on lymphocytes. (A) A schematic diagram of the IL-22R1 transgene driven by a mouse CD2 promoter. (B) Southern blot analysis of IL-22R1 transgene in founders on a C57BL/6 background. (C) Zebra plots of flow cytometric analysis for IL-22R1 expression on myeloid (CD11b+), T (CD3+), and B (CD19+) cells in peripheral blood leukocytes. (D) Western blot analysis of STAT3 phosphorylation (Tyr705) in the thymus, lymph nodes, and spleen from tg founders and nontransgenic littermates.

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