Transplantation of IL-22R1 tg hematopoietic cells into wt recipients results in T cell–mediated spontaneous multiorgan inflammation. (A) Schematic diagram showing serial bone marrow transplantation in tg (IL-22R1→wt) and wt (wt→wt) recipients. (B) Total cellularity of hematopoietic organs in wt (wt→wt) and tg (IL-22R1→wt) recipients. Gross morphology of the thymus (C), spleen (D), and lymph nodes (E). Images were acquired using a digital SLR camera (Sony DSLR-A330) with a Macro 2.8/50 lens. (F) Analysis of the concentrations of inflammatory cytokines (by CBA) and IL-22 (by ELISA) in the serum of IL-22R1 tg (IL-22R1→wt) and wt (wt→wt) recipients (n = 7). The data are represented as the mean ± SEM. *P < .05, **P < 0.01, ***P < .001. (G) Kaplan-Meier survival plot of wt and Foxn1^nu recipients receiving bone marrow from IL-22R1 tg mice. (H) Percentage of neutrophils (NE), lymphocytes (LY), monocytes (MO), eosinophils (EO), and basophils (BA) in peripheral blood lymphocytes from athymic nude mice compared with wt controls receiving IL-22R1 tg bone marrow.