Gene expression profiling of CD4⁺ T cells from patients with indolent B-cell malignancies compared with healthy donors 40 hours after in vitro stimulation. (A) Proportional Venn diagram of transcript numbers with highly significant (P < .001, Q < 0.05) up- or down-regulation in stimulated T cells. (B-C) Schematic diagram of the KEGG TCR signaling pathway (KEGG #4660). Fold changes in transcript levels between T cells from B-cell malignancies and age-matched healthy donors are color-coded according to the bar scale. NFAT box represents expression value of NFATc2; and RAS box, KRAS. For numerical values and statistical significance, see supplemental Table 2. (B) TCR signaling in FL/eMZL (n = 13) versus healthy donors. (C) TCR signaling in CLL (n = 8) versus healthy donors.