Cytokine profiles of stimulated CD4⁺ T cells from patients with indolent B-cell malignancies compared with healthy donors. Culture supernatants collected at 40 hours after anti-CD3/anti-CD28 stimulation were analyzed by cytometric bead arrays. (A) Cytokine concentrations in supernatants. Horizontal bars, boxes, and whiskers represent median, 25%/75% quartiles, and range, respectively. FL/eMZL, n = 13; CLL, n = 8 patients. (B) Calculated concentration ratios of IL-4 and IL-5 between culture supernatants of T cells from indolent lymphoma patients and their respective healthy donor. Comparison of concentration ratios between FL/eMZL and CLL patients.