Figure 1
Mechanisms of genesis and FISH analysis of variant translocations. Shown are the 1-step mechanism (A) and the 2-step mechanism (B). The segments in the open boxes exchange material, as shown by the curved arrows. The letters indicate the probe colors used in FISH studies: R for red, labeling the ABL1 gene sequence region; G for green, labeling the BCR green sequence region; and F for fusion.4 (C) Case n.17, 46, XY, t(9;9;22)(q34;q34;q11). (D) Case n.19, 46, XX, t(9;22;22)(q34;q11;q11), t(7;19)(q21;p13). (E) Case n.23, 46, XY, t(9;22;12)(q34;q11;q24). BCR is shown by the green signal, ABL by the red signal, and fusion by the green/red signal (see “Results”).
