Mutation profiles of VDJ-S regions from patients with WM and IgM MGUS. The horizontal bar at the top depicts the DNA segment amplified by CDR2 and Sw15as primers. Patient mutation profiles are aligned directly underneath; vertical lines indicate point mutations, triangles indicate deletions (176 bp in WM1-06 and 24 bp in WM1-01). Total point mutations in the 1.6-kb region (dark gray bar) are summarized to the right.