Influence of HLA-DPB1 mismatches on the outcome of UD-SCT for β-thalassemia. The probability of graft rejection (A), grade II-IV aGvHD (B), and TFS (C) was analyzed by cumulative incidence (A-B) or Kaplan-Meier estimates (C) in 72 (A,C) or 71 (B) evaluable patients. Patients and donors were classified as: (1) matched for HLA-DPB1 or with a permissive mismatch (solid line; n = 45); (2) matched for HLA-DPB1 with nonpermissive DPB1 mismatches in HvG direction (broken line; n = 17); (3) matched for HLA-DPB1 with nonpermissive DPB1 mismatches in GvH direction (dotted line; n = 10 [A,C] or n = 9 [B]), according to the algorithm we previously described.¹³