Comparison of clinical outcomes on total therapy 2 without thalidomide (TT2) and total therapy 1 (TT1). (A) Months to treatment step: median time to first and second transplantation 2 months earlier on TT2 compared with TT1. (B) Cumulative incidence of complete remission (CR): similar timing and frequency of CR with TT1 and TT2. (C) Duration of CR: CR duration for TT2 was significantly longer than for TT1. (D) Event-free survival: event-free survival was superior for TT2 compared with TT1. (E) Overall survival: overall survival tended to be superior on TT2 compared with TT1. (F) Cumulative incidence of treatment-related mortality (TRM): similar timing and frequency of TRM with TT1 and TT2.