Amino acid sequences of the HCDR3 and LCRD3 in the V_H3-21-using cases. The HCDR3 sequences are aligned to the most commonly occurring HCDR3 sequence (DANGMDV). Amino acids identical to the top sequence are indicated with a dot (.) and missing amino acids are indicated with a dash (-). Only the V_λ2-14 LCDR3 sequences are outlined, and an asterisk (^*) indicates that the case used a V_L gene other than V_λ2-14. Geographic origin of the patient is indicated in the case number: Germany (G), Sweden (S), Italy (I), United States (U), Finland (F), and Australia (A).