Kaplan-Meier survival curve analysis in V_H3-21⁺ CLL. (A) Comparison of V_H3-21⁺ patients with mutated and unmutated V_H rearrangements. No significant difference could be detected between the 2 subsets (log-rank test, P = .17); the median survival was 74 months for patients with mutated V_H3-21 genes, whereas the median survival was not reached for patients with unmutated V_H3-21 genes. (B) Comparison of V_H3-21⁺ patients with highly homologous HCDR3s versus nonhomologous HCDR3s. The highly homologous HCDR3s had a median overall survival of 104 months, while patients with nonhomologous HCDR3s had a median survival of 70 months (log-rank test, P = .32).