A schematic model of OSCAR gene regulation via transcription factors during osteoclastogenesis. M-CSF and TRANCE induce the formation of TRAP⁺ multinuclear osteoclasts from BMM. Upon stimulation, activated MAP kinases regulate transcription factors such as Mitf and NFATc1, subsequently leading to the up-regulation of the OSCAR gene during osteoclastogenesis. OSCAR and NFATc1 show positive feedback regulation.